Papers from the Rathmell lab

Altman, B.J., J.A. Wofford, Y. Zhao, J.L. Coloff, E.C. Ferguson, H.L. Wieman, O. Ilkaveya, J.C. Rathmell. 2008. Autophagy provides nutrients but leads to Chop-mediated induction of Bim to sensitize cells to apoptosis. Submitted.

Wieman, H.L., J.C. Rathmell. 2007. A C-terminal PDZ-binding motif in Glut1 protects from lysosomal targeting and promotes recycling to allow growth-factor stimulated glucose uptake. Submitted.

Jacobs, S.R., C.E. Herman, J. Hammen, J.C. Rathmell. 2007. Glucose Uptake is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and -Independent Pathways. J. Immunol 180:4476-86.

Wofford, J.A., H.L. Wieman, S.R. Jacobs, Y. Zhao, J.C. Rathmell. 2007. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt1 to support T cell survival. Blood 111:2101-11.

Juntilla, M.M*, J.A. Wofford*, M.J. Birnbaum, J.C. Rathmell, G Koretzky. 2007. Akt1 and Akt2 are required for immature ab thymocyte survival and differentiation. Proc. Natl. Acad Sci USA 104:12105-10. *These authors contributed equally. Note that J.A. Wofford is a student in the Rathmell lab and J.C. Rathmell and G. Koretzky are listed as co-corresponding authors on this manuscript.

Zhao, Y., B.J. Altman, J.L. Coloff, C.E. Herman, S.R. Jacobs, H.L. Wieman, J.A. Wofford, L.N. Dimascio, O. Ilkayeva, A. Kelekar, T. Reya, and J.C. Rathmell. 2007. GSK-3α/β Mediate a Glucose-Sensitive Anti-Apoptotic Signaling Pathway to Stabilize Mcl-1. Mol Cell Biol. 27:4328-39.

Wieman, H.L., J.A. Wofford, J.C. Rathmell. 2007. Cytokine Stimulation Promotes Glucose Uptake via PI3K/Akt Regulation of Glut1 Activity and Trafficking. Mol. Biol. Cell. 18:1437-46.

Boxer, R.B., D.B. Stairs, K.D. Dugan, K.L. Notarfrancesco, C.P. Portocarrero, B.A. Keister, G.K. Belka, H. Cho, J.C. Rathmell, C.B. Thompson, M.J. Birnbaum, L.A. Chodosh. 2006. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab. 4:375-490.

Nutt, L.K., S.S. Margolis, M. Jensen, C.E. Herman, W.G. Dunphy, J.C. Rathmell, S. Kornbluth. 2005. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of Caspase 2. Cell. 123:89-103. Article selected for cover art. See comment in Cell 123:3-5.

Cinalli, R.M., C.E. Herman, B. Lew, H.L. Wieman, K. Burridge, C.B. Thompson, J.C. Rathmell. 2005. T cell homeostasis requires GPCR-mediated access to trophic signals that promote growth and inhibit chemotaxis. Eur. J. Immunol. 35:786-795.

Reviews and Book Chapters

Rathmell, J.C., S. Kornbluth. 2007. Filling a GAP(DH) in Caspase-Independent Cell Death. Cell 129:861-863.

Coloff, J.L., J.C. Rathmell. 2006. Metabolic Regulation of Akt: Roles Reversed. J. Cell Biol. 175:845-847.

Jacobs, S.R., J.C. Rathmell. 2006. Lymphocyte Selection by Starvation: Glucose Metabolism and Cell Death. Trends in Immunology. 27:4-7.

Rathmell, J.C. 2004. B cell homeostasis: Digital survival or analog growth? Immunol Rev. 197:116-128.

Deming, P., J.C. Rathmell. Mitochondria, Cell Death, and B Cell Tolerance. In Apoptosis and Its Relevance to Autoimmunity: Curr. Dir. Autoimmunity. Elkon, K, (ed). Basel Karger Publishing, 2006, 9:95-119.

Rathmell, J.C. Apoptosis and B cell tolerance. In B Cell Biology and Autoimmunity: Curr. Dir. Autoimmunity. Nemazee, D. (ed). Basel, Karger Publishing, 2003, 6:38-60.

Selected Other Rathmell Publications

Bauer, D.E., M.H. Harris, D.R. Plas, J.J. Lum, P.S. Hammerman, J.C. Rathmell, J.L. Riley and Craig B. Thompson. 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB J. 18:1303-5.

Bensinger, S.J., P.T. Walsh, J. Zhang, M. Carrol, R. Parsons, J.C. Rathmell, C.B. Thompson, M.A. Burchill, M.A. Farrar, L.A. Turka. 2004. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J. Immunol. 172:5287-5296.

Rathmell, J.C., C.J. Fox, D.R. Plas, P. Hammerman, R.M. Cinalli, C.B. Thompson. 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23:7315-7328.

Rathmell, J.C., R.M. Cinalli, R.L. Elstrom, C.B. Thompson. 2003. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur. J. Immunol. 33:2223-2232.

Plas, D.R., J.C. Rathmell, C.B. Thompson. 2002. Homeostatic control of lymphocyte survival: potential origins and implications. Nature Immunol. 3: 515-21.

Rathmell, J.C., C.B. Thompson. 2002. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 109:S97-S107.

Rathmell, J.C., T. Lindsten, W.-X. Zong, R.M. Cinalli, C.B. Thompson. 2002. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature Immunol. 3:932-939. See comment in Nature Immunol. 3:893-894.

Frauwirth, K.A., J.L. Riley, M.H. Harris, R.V. Parry, J.C. Rathmell, D.R. Plas, R.L. Elstrom, C.H. June, C.B. Thompson. 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity 16:767-777.

Rathmell, J.C., E.A. Farkash, W. Gao, C.B. Thompson. 2001. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167:6869-6876.

Vander Heiden, M.G., D.R. Plas, J.C. Rathmell, C.J. Fox, M.H. Harris, C.B. Thompson. 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell Biol. 21:5899-912.

Plas, D.R., S. Talapatra, A.L. Edinger, J.C. Rathmell, C.B. Thompson. 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276:12041-8.

Lindsten, T., A.J. Ross, A. King, W.-X. Zong, J.C. Rathmell, H.A. Shiels, E. Ulrich, K.G. Waymire, P. Mahar, K. Frauwirth, Y. Chen, M. Wei, V.M. Eng, D.M. Adelman, M.C. Simon, A. Ma, J.A. Golden, G. Evan, S.J. Korsmeyer, G.R. MacGregor, C.B. Thompson. 2000. The combined functions of the pro-apoptotic Bcl-2 family members, Bak and Bax, are essential for the development of multiple tissues. Mol Cell 6:1389-99.

Rathmell, J.C., M.G. Vander Heiden, M.H. Harris, K.A. Frauwirth, C.B. Thompson. 2000. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6:683-692.

Rathmell, J.C., C.B. Thompson. 1999. The central effectors of cell death in the immune system. Annual Rev. of Immunol. 17:781-828.

Rathmell, J.C., S.E. Townsend, J.C. Xu, R.A. Flavell, C.C. Goodnow. 1996. Expansion or elimination of self-reactive B cells in vivo: dual roles for CD40- and Fas(CD95)-ligands modulated by the B cell antigen receptor. Cell 87:319-329.

Rathmell, J.C., M.P. Cooke, W.Y. Ho, J Grein, S.E. Townsend, M.M. Davis, C.C. Goodnow. 1995. CD95 (Fas/APO-1)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 376:181-184.

Rathmell, J.C., C.C. Goodnow. 1994. Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. J. Immunol. 153:2831-2842.