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The Rathmell Lab

Jeff Rathmell

Duke University Department of Pharmacology and Cancer Biology
Department of Immunology, Sarah W. Stedman Center for Nutrition and Metabolism
GFP-Glut1 (green) and Lysotracker (red) show intracellular distribution of the glucose transporter, Glut1, and lysosomes in growth factor stimulated lymphocytes
Electron microscopy of growth factor starved cell shows how cells that lose glucose uptake resort to autophagy prior to apoptosis by Bcl-2 family proteins
Our focus is to understand how metabolism is regulated in immunity and cancer as well as how glucose metabolism impacts cell differentiation and death pathways. Ultimately, we hope to manipulate metabolism in immunosuppressive and cancer therapies.
 

Duke University

Department of Pharmacology and Cancer Biology
Department of Immunology
Sarah W. Stedman Nutrition and Metabolism Center